Biomedical Sciences
Hugo Snippert uses microscopy and molecular genetics to understand how it is that there is a huge diversity of tumour cells and what the consequences of this are. This knowledge helps towards the tailoring of individual cancer therapies.
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Combining insights from genetics, microbiology and bioinformatics, Jingyuan Fu investigates the gut microbiome in relation to disease and health. She particularly focuses on complex diseases such as obesity and cardiovascular disease.
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Louis Vermeulen studies how derailments in the genetic material of stem cells can cause colon cancer. In doing so, he focuses specifically on the earliest development of tumors. He combines biochemistry and genetics with mathematical and physical models to map the dynamics of stem cells. With his innovative approach, he has made a major contribution to fundamental concepts within molecular oncology.
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Annemieke Aartsma-Rus has made an important contribution to research in Duchenne muscular dystrophy. Patients with this serious hereditary muscle disease lack the protein dystrophin, because the gene code for dystrophin is unreadable. Thanks in part to the fundamental pioneering work of Aartsma-Rus, an exon skipping therapy is now available in the USA and Japan that can make the genetic code readable again. This can slow down disease progression for Duchenne patients.
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Teun Bousema unravels the life cycle of Plasmodium falciparum, a parasite carried by mosquitoes that causes malaria. He is particularly interested in how a parasite from an infected human is then reintroduced to a new mosquito, and it was Bousema who discovered, among other things, that some people have an immune reaction that prevents this step from happening.
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Jacco van Rheenen developed a groundbreaking form of microscopy, allowing individual cells to be tracked for weeks in a living organism. This new form of research provides valuable information about the behaviour of, and the interaction between, cells. For example, he was the first person to film the process of metastatic cancer.
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Jeroen Geurts was a pioneer in tracking difficult to detect abnormalities in the brains of MS patients. In the course of this work he came up with a new theory about the cause of MS, one which fundamentally differs from the theory that most of his colleagues have adhered to for many years.
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Eva van Rooij was the first person to discover that microRNA molecules, components of living cells which have only recently been discovered, play a role in heart diseases. She is now investigating other molecular mechanisms that affect our cardiac cells. Is it possible to influence these so as to limit damage to such cells or even reverse it?
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Eye-diseases are rapidly becoming more significant: there are already more than 300,000 blind and visually impaired people in the Netherlands. Due to the aging population this number will increase explosively in the coming years. Caroline Klaver is a scientific researcher and ophthalmologist, and a driving force behind research into the root causes of some of the most common eye problems.
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Thijn Brummelkamp is an energetic, critical and entrepreneurial scientist researching the function of each of the approximately 25,000 genes in the human body. He began by developing a way to turn off each of these genes one by one. Then he invented an even smarter method to do the same with a number of genes at the same time.
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